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Compact Temperature Control for Medical Diagnostic and Analytical Instrumentation

Introduction

The trend to miniaturize medical diagnostic and analytical instrumentation to free up precious lab space has led engineers to pack more functionality into a tighter space constraint. This increases the heat flux by packing electronics in a smaller footprint and has led to thermal challenges. Waste heat must be efficiently managed to meet conflicting requirements of increased performance with reduced power consumption and quieter operation all in a compact design.




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Next Generation Thermoelectrics Designed for Real-Time PCR

Introductions

Polymerase chain reaction (PCR) is a technique used in molecular diagnostics to amplify sequencing of DNA. Also referred to as molecular photocopying, the DNA produced by PCR is vital to many laboratory and clinical procedures. PCR testing has been instrumental in the diagnosis of SARS-CoV-2, better known as COVID-19. Not only do PCR tests detect the presence of a virus during testing but it will also detect fragments of a virus even after the patient is no longer infected.




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DNA Amplification

PCR is enabled by a machine called a thermocycler, which rapidly heats and cools the DNA sample to a defined series of temperature steps.

Modern thermocyclers used for real-time and digital PCR testing utilize Peltier technology to precisely manage the set point temperatures and ramp rates. This is a harsh environment for standard thermoelectric coolers due to the mechanical stresses that occur during the heating and cooling stage.

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